Identification of a pancreatic stellate cell gene signature and lncRNA interactions associated with type 2 diabetes progression.

ABSTRACT:

Background

Type 2 diabetes (T2D) has become a significant global health threat, yet its precise causes and mechanisms remain unclear. This study aims to identify gene expression patterns specific to T2D pancreatic islet cells and to explore the potential role of pancreatic stellate cells (PSCs) in T2D progression through regulatory networks involving lncRNA-mRNA interactions.

Methods

In this study, we screened for upregulated genes in T2D pancreatic islet samples using bulk sequencing (bulkseq) datasets and mapped these gene expression profiles onto three T2D single-cell RNA sequencing (scRNAseq) datasets. The identified T2D-specific gene features were further validated in an additional T2D scRNAseq dataset, a T1D scRNAseq dataset, and a T2D bulkseq dataset. To investigate r

SUBMITTER: Qiu J 

PROVIDER: S-EPMC11769806 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature