The immune landscape of fetal chorionic villous tissue in term placenta.

ABSTRACT:

Introduction

The immune compartment within fetal chorionic villi is comprised of fetal Hofbauer cells (HBC) and invading placenta-associated maternal monocytes and macrophages (PAMM). Recent studies have characterized the transcriptional profile of the first trimester (T1) placenta; however, the phenotypic and functional diversity of chorionic villous immune cells at term (T3) remain poorly understood.

Methods

To address this knowledge gap, immune cells from human chorionic villous tissues obtained from full-term, uncomplicated pregnancies were deeply phenotyped using a combination of flow cytometry, single-cell RNA sequencing (scRNA-seq, CITE-seq) and chromatin accessibility profiling (snATAC-seq).

Results

Our results indicate that, relative to the first trimester, t

SUBMITTER: Doratt BM 

PROVIDER: S-EPMC11769816 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature