The bronchoalveolar lavage fluid <i>CD44</i> as a marker for pulmonary fibrosis in diffuse parenchymal lung diseases.

ABSTRACT:

Introduction

Diffuse parenchymal lung diseases (DPLD) cover heterogeneous types of lung disorders. Among many pathological phenotypes, pulmonary fibrosis is the most devastating and represents a characteristic sign of idiopathic pulmonary fibrosis (IPF). Despite a poor prognosis brought by pulmonary fibrosis, there are no specific diagnostic biomarkers for the initial development of this fatal condition. The major hallmark of lung fibrosis is uncontrolled activation of lung fibroblasts to myofibroblasts associated with extracellular matrix deposition and the loss of both lung structure and function.

Methods

Here, we used this peculiar feature in order to identify specific biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluids (BALF). The primary MRC-5 human fibrob

SUBMITTER: Suchankova M 

PROVIDER: S-EPMC11769834 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature