Evaluation of an automated laminar cartilage T2 relaxation time analysis method in an early osteoarthritis model.

ABSTRACT:

Objective

A fully automated laminar cartilage composition (MRI-based T2) analysis method was technically and clinically validated by comparing radiographically normal knees with (CL-JSN) and without contra-lateral joint space narrowing or other signs of radiographic osteoarthritis (OA, CL-noROA).

Materials and methods

2D U-Nets were trained from manually segmented femorotibial cartilages (n = 72) from all 7 echoes (All_E), or from the 1st echo only (1^st_E) of multi-echo-spin-echo (MESE) MRIs acquired by the Osteoarthritis Initiative (OAI). Because of its greater accuracy, only the All_E U-Net was then applied to knees from the OAI healthy reference cohort (n = 10), CL-JSN (n = 39), and (1:1) matched CL-noROA knees (n = 39) that all ha

SUBMITTER: Wirth W 

PROVIDER: S-EPMC11769870 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature