AIP56, an AB toxin secreted by <i>Photobacterium damselae</i> subsp. <i>piscicida</i>, has tropism for myeloid cells.

ABSTRACT:

Introduction

The AB-type toxin AIP56 is a key virulence factor of Photobacterium damselae subsp. piscicida (Phdp), inducing apoptosis in fish immune cells. The discovery of AIP56-like and AIP56-related toxins in diverse organisms, including human-associated Vibrio strains, highlights the evolutionary conservation of this toxin family, suggesting that AIP56 and its homologs may share conserved receptors across species. These toxins have potential for biotechnological applications, such as therapeutic protein delivery and immune modulation.

Methods

Herein, the cell specificity of AIP56 for immune cells was characterized. The tropism of AIP56 for cells of the sea bass, mouse and human immune system was analyzed by following toxin internalization by flow cytometry and arrival of

SUBMITTER: Freitas IL 

PROVIDER: S-EPMC11769971 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature