Comparative transcriptomic rhythms in the mouse and human prefrontal cortex.

ABSTRACT:

Introduction

Alterations in multiple subregions of the human prefrontal cortex (PFC) have been heavily implicated in psychiatric diseases. Moreover, emerging evidence suggests that circadian rhythms in gene expression are present across the brain, including in the PFC, and that these rhythms are altered in disease. However, investigation into the potential circadian mechanisms underlying these diseases in animal models must contend with the fact that the human PFC is highly evolved and specialized relative to that of rodents.

Methods

Here, we use RNA sequencing to lay the groundwork for translational studies of molecular rhythms through a sex-specific, cross species comparison of transcriptomic rhythms between the mouse medial PFC (mPFC) and two subregions of the human PFC,

SUBMITTER: Burns JN 

PROVIDER: S-EPMC11769989 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature