β-ecdysone/PLGA composite scaffolds promote skull defect healing in diabetic rat.

ABSTRACT:

Introduction

Diabetes mellitus often leads to bone metabolism disorders, hindering bone regeneration and delaying the healing of bone defects. β-Ecdysone, a plant-derived hormone known for its wide range of physiological activities, possesses hypoglycemic effects and promotes osteogenic differentiation. This study developed a composite PLGA slow-release scaffold loaded with β-ecdysone to enhance its bioavailability through topical administration and to investigate its potential to heal diabetic bone defects.

Methods

The composite scaffolds were fabricated using solution casting/particle leaching and freeze-drying techniques. Then a series of characterizations were subjected to test the performance of composite scaffolds, and in vitro safety of the composite scaffolds

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11770018 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature