The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children.

ABSTRACT: Acute respiratory infections (ARI) with multiple types of viruses are common in infants and children. This study was conducted to assess the difference of oropharyngeal microbiome during acute respiratory viral infection using whole-genome shotgun metagenomic sequencing. The overall taxonomic alpha diversity did not differ by the types of infected virus. The beta diversity differed by disease severity, disease-related symptoms, and types of infected virus. Nine species had significantly higher abundance in outpatients than in inpatients, with five of them in the genus Achromobacter. Three microbial community types were identified. The prevalence of community type (CT) 1 was higher among patients with influenza virus, enterovirus, and human adenvirus; CT2 was higher among patients with huma

SUBMITTER: Wu Z 

PROVIDER: S-EPMC11770077 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature