Preparation of curcumin submicron particles by supercritical antisolvent method with external adjustable annular gap nozzle.

ABSTRACT: The supercritical antisolvent (SAS) method can effectively improve the bioavailability of poorly water-soluble drugs. However, the current supercritical equipment and processes were not fully developed, making industrialization difficult to achieve. Therefore, an externally adjustable annular gap nozzle and its supporting equipment were designed. Curcumin was used as a model drug, ethanol as the solvent, and supercritical carbon dioxide (SC-CO₂) as the antisolvent. Building on single-factor experiments, a Box-Behnken Design-Response Surface Methodology (BBD-RSM) was employed to systematically investigate the effects of four process parameters-crystallizer pressure (12-16 MPa), crystallizer temperature (313-323 K), solution concentration (1-2 mg/mL), and CO₂/solution f

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11770171 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature