Association between frailty index and mortality in depressed patients: results from NHANES 2005-2018.

ABSTRACT: This study investigated the relationship between the frailty index and all-cause and cause-specific mortality in patients with depression. We recruited 2,669 participants with depression from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 and quantified their frailty status using a 53-item frailty index. Cox proportional hazards models were used to estimate hazard ratios (HR) and their 95% confidence intervals (CI). The median (IQR) frailty score was 0.3 (0.2, 0.4). During a median follow-up of 7.1 years, 342 all-cause deaths (including 85 cardiovascular deaths and 70 cancer deaths) were recorded. Compared to the lowest frailty index tertile, the adjusted HR (95% CI) for all-cause mortality in the highest tertile was 2.91 (1.97, 4.3), for cardiovascular mor

SUBMITTER: Liu X 

PROVIDER: S-EPMC11770190 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature