Cardiovascular disease attenuates the protective effect of folate on global cognitive function in an elderly population: a cross-sectional study.

ABSTRACT: Research suggests that folic acid contributes to improving cognitive function. However, there is a lack of systematic research on the association of dietary intake of folate and serum, and red blood cell (RBC) folate levels with global cognitive impairment (CoI) in the elderly population. Importantly, excessive supplementation with folate among American adults at high risk of cardiovascular disease (CVD) may have harmful effects. CVD often leads to worse cognitive function; therefore, it is necessary to explore the characteristics of the association of folate with CoI in both CVD and non-CVD populations. Participants aged ≥ 60 years from the national health and nutrition examination survey (NHANES) 2011-2014 were included. Dietary intake of folate and serum and RBC folate levels were deter

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11770194 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature