Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.

ABSTRACT: Future long duration space missions will expose astronauts to higher doses of galactic cosmic radiation (GCR) than those experienced on the international space station. Recent studies have demonstrated astronauts may be at risk for cardiovascular complications due to increased radiation exposure and fluid shift from microgravity. However, there is a lack of direct evidence on how the cardiovascular system is affected by GCR and microgravity since no astronauts have been exposed to exploratory mission relevant GCR doses. Therefore, we utilized a ground-based mouse model to determine the cardiovascular risks for space radiation exposure while the mice were simultaneously hindlimb suspended to mimic microgravity. 6-month-old male and female C57BL/6 mice were exposed to an absorbed dose of 0 G

SUBMITTER: Nemec-Bakk AS 

PROVIDER: S-EPMC11770252 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature