Correlates of Protection Against Symptomatic COVID-19: The CORSER 5 Case-Control Study.

ABSTRACT:

Background

Establishing correlates of protection often requires large cohorts. A rapid and adaptable case-control study design can be used to identify antibody correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in serum and saliva.

Methods

We designed a case-control study to compare antibody levels between cases of SARS-CoV-2 infection within 5 days of symptom onset and uninfected controls. Controls were matched on age, number of coronavirus disease 2019 vaccine doses, time since last dose, and past episodes of infection. We quantified anti-SARS-CoV-2 and seasonal coronavirus immunoglobulin (Ig) G in serum and saliva at inclusion, 1 month, and 6 months.

Results

We included 90 cases and 62 controls between February a

SUBMITTER: Beeker L 

PROVIDER: S-EPMC11770277 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature