Intercellular Epigenomic Signalling via Extracellular Vesicles During B Cell Maturation.

ABSTRACT: B cell maturation is crucial for effective adaptive immunity. It requires a complex signalling network to mediate antibody diversification through mutagenesis. B cells also rely on queues from other cells within the germinal centre. Recently, a novel class of intercellular signals mediated by extracellular vesicles (EVs) has emerged. Studies have shown that B cell EV-mediated signalling is involved in immune response regulation and tumorigenesis. However, the mechanistic role of B cell EVs is not yet established. We herein study the biological properties and physiological function of B cell EVs during B cell maturation. We use emerging technologies to profile B cell EV surface marker signatures at the single particle level, molecular cargo and physiological roles in B cell maturation. EV n

SUBMITTER: Yim KHW 

PROVIDER: S-EPMC11770373 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature