Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men.

ABSTRACT:

Background

Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unclear and difficult to disentangle from that of androgens. In this study, we examined the metabolic changes induced by FSH and distinguished them from those caused by testosterone.

Methods

Plasma samples from temporarily medically castrated young men (n = 33) treated with FSH and/or testosterone were characterized by proteomics and metabolomics approaches. All subjects received GnRH a

SUBMITTER: Guedes J 

PROVIDER: S-EPMC11770401 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature