Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure.

ABSTRACT:

Background

The model for end-stage liver disease (MELD) score is widely used for the prognostication in end-stage liver disease but has limited performance in acute-on-chronic liver failure (ACLF). In this study, we identified additional predictive parameters and reformed the MELD score to predict ACLF more accurately.

Methods

A meta-analysis was performed on relevant studies to identify the predictive factors of 28-day/90-day outcomes of ACLF, which were validated in two large prospective cohorts. A prognostic score was developed by incorporating predictive parameters into the MELD score. The model was evaluated with a focus on discrimination and calibration.

Results

The meta-analysis incorporated 32 cohort studies with a total of 13 939 patients, of which 13 risk fa

SUBMITTER: Yu X 

PROVIDER: S-EPMC11770428 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature