Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach.

ABSTRACT:

Abstract

Background

The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders.

Methods

Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked to IBS. Subsequently, multiresponse MR (MR²) was employed to further examine these associations. Summary-level genome-wide association data were used. Modifiable factors and coexisting disorders (ie, gastrointestinal and psychiatric disorders) were identified based on evidence from cohort studies and meta-

SUBMITTER: Liu D 

PROVIDER: S-EPMC11770431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature