CLivD score modifies FIB-4 performance in liver fibrosis detection in the US general population.

ABSTRACT:

Abstract

Background and aims

Steatotic liver disease (SLD) is a growing global concern. The Chronic Liver Disease (CLivD) risk score predicts liver-related outcomes in the general population using easily accessible variables with or without laboratory tests (CLivD_lab and CLivD_non-lab). We assessed CLivD's associations with liver steatosis, fibrosis and its combined performance with fibrosis-4 (FIB-4) for advanced fibrosis detection.

Methods

Using the National Health and Nutrition Examination Survey data (2017-2020), 3603 participants aged 40-70 years with valid liver stiffness measurements (LSMs) were included. Advanced fibrosis was defined as LSM ≥12 kPa, and SLD as controlled attenuation parameter ≥288 dB/m.

Results

Significant associat

SUBMITTER: Aberg F 

PROVIDER: S-EPMC11770440 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature