Comprehensive Chemical Analysis of the Methyl 3-Nitrogen-2,3-Dideoxysaccharides Derivatives with d-<i>ribo</i>-Configuration: Synthesis, Reactivity of HIV-1 Reverse Transcriptase Inhibitors.

ABSTRACT: This study extends previous research, particularly focusing on patented scientific objects No. ID: PL 240 353 B1, investigating the physicochemical properties of the methyl 3-azido- and 3-amino-2,3-dideoxysaccharides with a nucleoside scaffold similar to 3'-azidothymidine (AZT). The study utilizes multiwavelength spectrophotometric and potentiometric methods to evaluate the ionization of the saccharide units in aqueous solutions. pK_a values, obtained from two independent methods, reveal significant sugar ionization effects on UV spectra with varying pH levels. Stability constants for divalent metal ion complexes (Cu²⁺ and Ni²⁺) with the saccharide isomers indicate that complex stoichiometries and stabilities are highly dependent on the configuration

SUBMITTER: Dabrowska AM 

PROVIDER: S-EPMC11770755 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature