A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway.

ABSTRACT:

Context

The decline in ovarian reserve is a major concern in female reproductive health, often associated with oxidative stress and mitochondrial dysfunction. Although ginsenoside Rg1 is known to modulate mitophagy, its effectiveness in mitigating ovarian reserve decline remains unclear.

Objective

To investigate the role of ginsenoside Rg1 in promoting mitophagy to preserve ovarian reserve.

Materials and methods

Ovarian reserve function, reproductive capacity, oxidative stress levels, and mitochondrial function were compared between ginsenoside Rg1-treated and untreated naturally aged female Drosophila using behavioral, histological, and molecular biological techniques. The protective effects of ginsenoside Rg1 were analyzed in a Drosophila model of oxid

SUBMITTER: Yang P 

PROVIDER: S-EPMC11770866 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature