Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis.

ABSTRACT:

Background

Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. In this study, we aimed to investigate the value of differentially expressed tsRNAs in LC through meta-analysis.

Methods

PubMed and Web of Science were searched for articles published up to January 10, 2024. Diagnostic odds ratios (DORs) and areas under the receiver operating characteristic curve (AUCs) were used to evaluate the potential of tsRNAs as diagnostic markers for LC. Furthermore, hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to analyze association of tsRNAs with LC prognosis.

Results

In total, 12 studies were included in the analysis. Our

SUBMITTER: Tang C 

PROVIDER: S-EPMC11770914 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature