Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE^-/- mice.

ABSTRACT:

Background

Atherosclerosis (AS) is a major contributor to vascular disorders and represents a significant risk to human health. Currently, first-line pharmacotherapies are associated with substantial side effects, and the development of atherosclerosis is closely linked to dietary factors. This study evaluated the effects of a dietary supplement, EsV3, on AS in apolipoprotein E (ApoE) ^-/- model mice.

Methods

The study utilized a high-fat diet-induced ApoE^-/- hyperlipidemic mouse model. EsV3 was administered in prophylactic (P-EsV3) and therapeutic regimens for 16 and 12 weeks, respectively, with distinct high- and low-dose groups (0.36 and 1.8 g/kg/day). Serum lipid levels were measured and monitored for body weight and food consumption alterations in m

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11770915 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature