MiR-208a-3p discriminates osteoporosis, predicts fracture, and regulates osteoclast activation through targeting STC1.

ABSTRACT:

Background

Osteoporosis (OP) frequently occurs in post-menopausal women, increasing the risk of fracture. Early screening OP could improve the prevention of fractures.This study focused on the significance of miR-208a-3p in diagnosing OP and development regulation, aiming to explore a novel biomarker and therapeutic target for OP.

Methods

The study enrolled a total of 154 post-menopausal women and grouping was performed based on the incidence of OP and fracture. The significance of miR-208a-3p was evaluated from the perspectives of menopausal correlation, OP diagnosis, and fracture prediction. In mechanism, the regulatory effect and mechanism of miR-208a-3p on osteoclast activation was investigated.

Results

miR-208a-3p was menopause-related showing a negative correlat

SUBMITTER: Qian H 

PROVIDER: S-EPMC11770935 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature