Association of Alzheimer's and Lewy body disease pathology with basal forebrain volume and cognitive impairment.

ABSTRACT:

Background

Degeneration of the basal forebrain cholinergic system is a hallmark feature shared by Alzheimer's disease (AD) and Lewy body disease (LBD) whereas hippocampus atrophy is more specifically related to AD. We aimed to investigate the relationship between basal forebrain and hippocampus atrophy, cognitive decline, and neuropathology in a large autopsy sample.

Methods

Data were obtained from the National Alzheimer's Coordinating Center (NACC). Basal forebrain and hippocampus volumes were extracted using an established automated MRI volumetry approach. Associations of regional volumes with pathological markers (Braak stage, CERAD score, and McKeith criteria for LB pathology) and cognitive performance were assessed using Bayesian statistical methods.

Results

We i

SUBMITTER: Schumacher J 

PROVIDER: S-EPMC11771035 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature