Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients.

ABSTRACT:

Background

Ciprofol, a novel intravenous anesthetic, which has primarily been used for the induction and maintenance of general anesthesia in adults, is characterized by rapid onset, short duration of action, and quick and smooth recovery. However, the pharmacokinetic characteristics of continuous infusions and the correlation between the plasma concentration and the bispectral index (BIS) in elderly patients are still unknown.

Method

In this randomized, controlled study, thirty elderly patients (62-78 years old) undergoing elective gastrointestinal tumor resection were treated with propofol (N = 15) or ciprofol (N = 15) as sedatives during anesthesia. After induction, ciprofol/propofol was continuously infused intravenously until the end of the operation. Perioperative vita

SUBMITTER: Guo X 

PROVIDER: S-EPMC11771128 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature