Kehuang capsule inhibits MAPK and AKT signaling pathways to mitigate CCl₄-induced acute liver injury.

ABSTRACT:

Background and aims

Kehuang (KH) capsule is an herbal medical product approved for the treatment of liver diseases, including liver injury, in China. However, the mechanism is still unclear. This study aimed to elucidate the protective effects of KH capsule against carbon tetrachloride (CCl₄)-induced acute liver injury (ALI) in a murine model.

Methods

Mice were randomly divided into control, model (CCl₄), CCl₄+KH_Low and CCl₄+KH_High group. Liver enzyme levels and histological changes were assessed to evaluate liver injury. Oxidative stress markers and inflammatory cell infiltration in liver tissues were measured. Additionally, network pharmacology was employed to explore the potential mechanisms of KH capsule.

Results

KH ca

SUBMITTER: Ni Q 

PROVIDER: S-EPMC11771260 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature