Growth differentiation factor 7 alleviates the proliferation and metastasis of hepatocellular carcinoma.

ABSTRACT:

Background and aims

Inflammatory factors play significant roles in the development and occurrence of hepatocellular carcinoma (HCC). However, the tumor-protective functions of growth differentiation factors (GDFs) in HCC are yet to be clarified. In this study, we aimed to evaluate the expression levels of 10 GDFs in tumor and paratumor tissues from patients with HCC and perform in vitro and in vivo experiments to elucidate the role of GDF7 in regulating the proliferation and metastasis of HCC.

Methods

The gene expression of 10 GDFs was compared between HCC and paratumors using The Cancer Genome Atlas dataset and patient-derived tissues. A tumor microarray containing 108 HCC tissue samples was used to explore the prognostic value of GDF7 expression. Loss-of-func

SUBMITTER: Zhuo J 

PROVIDER: S-EPMC11771277 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature