Are depressive symptoms associated with biological aging in a cross-sectional analysis of adults over age 50 in the United States.

ABSTRACT: Major depressive disorder accelerates DNA methylation age, a biological aging marker. Subclinical depressive symptoms are common, but their link to DNA methylation aging in older adults remains unexplored. This study analyzed the cross-sectional relationship between depressive symptoms and accelerated DNA methylation aging, considering gender and race/ethnicity in U.S. adults aged over 50. We used data from 3,882 diverse participants in the 2016 Health and Retirement Study wave, measuring blood DNA methylation age against chronologic age for acceleration. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression evaluated the association between depressive symptoms and DNA methylation age acceleration, adjusting for so

SUBMITTER: Wang H 

PROVIDER: S-EPMC11771371 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature