Placental Pathology and Blood Pressure at Age 7: A Longitudinal Discordant Twin Analysis.

ABSTRACT:

Background

Evidence suggests that the intrauterine environment shapes offspring cardiovascular disease risk. Although placental dysfunction may be an important pathophysiologic pathway, numerous parental and pregnancy characteristics that influence offspring blood pressure are strong confounders of the mechanistic role of the placenta in observational analyses of singletons. Therefore, we leverage twin- and sibling-based comparison designs to determine whether placental pathology is associated with offspring blood pressure at age 7 while mitigating major sources of confounding.

Methods

Data are from pregnant participants and their offspring in the Collaborative Perinatal Project, a longitudinal pregnancy cohort conducted from 1959 to 1965 in the United States. After delivery

SUBMITTER: Freedman AA 

PROVIDER: S-EPMC11771519 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature