NK Count and Natural Cytotoxicity in Immune Nonresponders Versus Responders Living With HIV.

ABSTRACT: Despite viral suppression with antiretroviral therapy, immune nonresponders (INR) among people living with HIV (PLWH) still have a higher risk of developing AIDS-related and non-AIDS-related complications. Our study aimed to investigate the phenotype and functions of Natural Killer (NK) cells in INR, to better understand underlying mechanisms of immune nonresponse. Our cross-sectional study included PLWH aged over 45 with an undetectable HIV viral load sustained for at least 2 years. Participant CD4⁺ T-cell counts exceeded 500 cells/mm³ for IR or below 350 cells/mm³ for INR. We characterized NK cell subsets, performed natural cytotoxicity and ADCC assays, and phenotyped NK cells before and after functional assays. Median CD4 levels were 247.5 (IQR, 208.8-28

SUBMITTER: Silvestre C 

PROVIDER: S-EPMC11771562 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature