Comparison of Three Physician Global Assessment Instruments in Systemic Sclerosis.

ABSTRACT:

Objective

Physician global assessments (PhyGAs) are variably applied in systemic sclerosis (SSc) clinical trials. The comparability of different PhyGA results is unknown. We sought to assess the comparability of results from three different PhyGA instruments simultaneously applied in the Australian Scleroderma Cohort Study (ASCS).

Methods

Using data from 1,965 ASCS participants, we assessed the correlation between results of three PhyGA assessments: (1) overall health, (2) activity, and (3) damage. We evaluated the concordance of change in each PhyGA between study visits. Ordered logistic regression analysis was used to evaluate the clinical associations of each PhyGA.

Results

The absolute scores of each PhyGA were strongly correlated at individual study visits. Conco

SUBMITTER: Ross L 

PROVIDER: S-EPMC11771564 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature