Prognosis and clinicopathological features of patients with early-onset and late-onset colorectal cancer with second primary malignancies.

ABSTRACT:

Background and aim

The risk of developing a second primary malignancy differs among colorectal cancer patients in different age groups. This study aimed to investigate the differences in prognosis and clinicopathological features of patients with early-onset colorectal cancer and late-onset colorectal cancer who developed second primary malignancies.

Methods

The study included 15 489 patients who underwent surgery for colorectal cancer at Fudan University Shanghai Cancer Center between January 2008 and December 2018. Data pertaining to these patients were derived from the database.

Results

A total of 680 (4.5%) patients subsequently developed a second primary malignancy. Considering death as a competing event, the 10-year cumulative risk of second primary malignancy f

SUBMITTER: Chen F 

PROVIDER: S-EPMC11771649 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature