Rodent model of metabolic dysfunction-associated fatty liver disease: a systematic review.

ABSTRACT: Although significant progress has been made in developing preclinical models for metabolic dysfunction-associated steatotic liver disease (MASLD), few have encapsulated the essential biological and clinical outcome elements reflective of the human condition. We conducted a comprehensive literature review of English-language original research articles published from 1990 to 2023, sourced from PubMed, Embase, and Web of Science, aiming to collate studies that provided a comparative analysis of physiological, metabolic, and hepatic histological characteristics between MASLD models and control groups. The establishment of a robust metabolic dysfunction-associated steatotic liver rodent model hinges on various factors, including animal species and strains, sex, induction agents and methodologie

SUBMITTER: Cui XS 

PROVIDER: S-EPMC11771679 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature