Identification of key regulators in pancreatic ductal adenocarcinoma using network theoretical approach.

ABSTRACT: Pancreatic Ductal Adenocarcinoma (PDAC) is a devastating disease with poor clinical outcomes, which is mainly because of delayed disease detection, resistance to chemotherapy, and lack of specific targeted therapies. The disease's development involves complex interactions among immunological, genetic, and environmental factors, yet its molecular mechanism remains elusive. A major challenge in understanding PDAC etiology lies in unraveling the genetic profiling that governs the PDAC network. To address this, we examined the gene expression profile of PDAC and compared it with that of healthy controls, identifying differentially expressed genes (DEGs). These DEGs formed the basis for constructing the PDAC protein interaction network, and their network topological properties were calculated.

SUBMITTER: Bhattacharjee K 

PROVIDER: S-EPMC11771905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature