Generalized functional varying-index coefficient model for dynamic synergistic gene-environment interactions with binary longitudinal traits.

ABSTRACT: The genetic basis of complex traits involves the function of many genes with small effects as well as complex gene-gene and gene-environment interactions. As one of the major players in complex diseases, the role of gene-environment interactions has been increasingly recognized. Motivated by epidemiology studies to evaluate the joint effect of environmental mixtures, we developed a functional varying-index coefficient model (FVICM) to assess the combined effect of environmental mixtures and their interactions with genes, under a longitudinal design with quantitative traits. Built upon the previous work, we extend the FVICM model to accommodate binary longitudinal traits through the development of a generalized functional varying-index coefficient model (gFVICM). This model examines how the

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11771918 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature