Association of systemic inflammatory markers with white matter hyperintensities and microstructural injury: an analysis of UK Biobank data.

ABSTRACT:

Background

White matter damage is closely associated with cognitive and psychiatric symptoms and is prevalent in cerebral small vessel disease (CSVD); although the pathophysiological mechanisms involved in CSVD remain elusive, inflammation plays a crucial role. We sought to investigate the relationship between systemic inflammation markers and imaging markers of CVSD, namely white matter hyperintensity (WMH) and microstructural injury.

Methods

We conducted a study involving both cross-sectional and longitudinal data from the UK Biobank Cohort. We performed multiple linear regression analyses, adjusted for potential confounders, to explore the associations between systemic inflammation markers (e.g., systemic immune-inflammation index [SII], neutrophil-to-lymphocyte ratio [NL

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC11771994 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature