Brain-Cognition Fingerprinting via Graph-GCCA with Contrastive Learning.

ABSTRACT: Many longitudinal neuroimaging studies aim to improve the understanding of brain aging and diseases by studying the dynamic interactions between brain function and cognition. Doing so requires accurate encoding of their multidimensional relationship while accounting for individual variability over time. For this purpose, we propose an unsupervised learning model (called Contrastive Learning-based Graph Generalized Canonical Correlation Analysis (CoGraCa)) that encodes their relationship via Graph Attention Networks and generalized Canonical Correlational Analysis. To create brain-cognition fingerprints reflecting unique neural and cognitive phenotype of each person, the model also relies on individualized and multimodal contrastive learning. We apply CoGraCa to longitu

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11772010 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature