Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. While multiple studies have indicated changes in the expression of specific matrix metalloproteinases (MMPs) in patients with DN, and basic research has reported the impact of MMPs on DN, there is a lack of systematic research and the causal relationship remains unclear. The objective of this research is to investigate the casual relationship between MMPs and DN through two-sample Mendelian randomization (MR).

Methods

Data for this investigation were derived from genome-wide association studies (GWAS) of MMPs and DN. For the analysis using two-sample MR, methods such as inverse variance weighted (IVW), weighted median, wei

SUBMITTER: Bai C 

PROVIDER: S-EPMC11772099 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature