Effects of short-term exposure to moderate amounts of alcohol on brain volume.

ABSTRACT:

Aim

Although numerous studies have reported that chronic alcohol consumption causes brain volume reduction and cerebrospinal fluid volume increase, few studies have examined the acute effects of alcohol on brain structure. This study aims to investigate the short-term brain volume changes following alcohol administration.

Methods

Moderate doses of alcohol were administered intravenously to 18 healthy volunteers for a total of 90 min to achieve a blood alcohol concentration of 0.5 mg/mL. An alcohol clamp method combined with physiologically based pharmacokinetic modeling was used to achieve fine control over blood alcohol concentration. T1 images with 3T MRI were scanned at three time points: baseline, 0 min, and 90 min after the end of alcohol administration. Cortical, subco

SUBMITTER: Tsugawa S 

PROVIDER: S-EPMC11772103 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature