The Temporal Relation of Physical Function with Cognition and the Influence of Brain Health in the Oldest-Old.

ABSTRACT:

Introduction

Physical function and cognition seem to be interrelated, especially in the oldest-old. However, the temporal order in which they are related and the role of brain health remain uncertain.

Methods

We included 338 participants (mean age 93.1 years) from two longitudinal cohorts: the UCI 90+ Study and EMIF-AD 90+ Study. We tested the association between physical function (Short Physical Performance Battery, gait speed, and handgrip strength) at baseline with cognitive decline (MMSE, memory tests, animal fluency, Trail Making Test (TMT-) A, and digit span backward) and the association between cognition at baseline with physical decline (mean follow-up 3.3 years). We also tested whether measures for brain health (hippocampal, white matter lesion, and gray matter volu

SUBMITTER: Legdeur N 

PROVIDER: S-EPMC11772116 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature