Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis.

ABSTRACT:

Introduction

Remyelination of demyelinated axons can occur as an endogenous repair mechanism in multiple sclerosis (MS), but its efficacy varies between both MS individuals and lesions. The molecular and cellular mechanisms that drive remyelination remain poorly understood. Here, we studied the relation between microglia activation and remyelination activity in MS.

Methods

We correlated regenerative (CD163⁺) and inflammatory (iNOS⁺) microglia with BCAS1⁺ oligodendrocytes, subdivided into early-stage (<3 processes) and late-stage (≥3 processes) cells in brain donors with high or low remyelinating potential in remyelinated lesions and active lesions with ramified/amoeboid (non-foamy) or foamy microglia. A cohort of MS donors categorized as effi

SUBMITTER: Chen JQA 

PROVIDER: S-EPMC11772157 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature