Transcriptional signature of CD56^bright NK cells predicts favourable prognosis in bladder cancer.

ABSTRACT: Human natural killer (NK) cells can be sub-divided into two functional subsets but the clinical significance of these CD56^bright and CD56^dim NK cells in anti-tumour immunity remains largely unexplored. We determined the relative abundances of gene signatures for CD56^bright and CD56^dim NK cells along with 3 stromal and 18 other immune cell types in the patient tumour transcriptomes from the cancer genome atlas bladder cancer dataset (TCGA-BLCA). Using this computational approach, CD56^bright NK cells were predicted to be the more abundant tumour-infiltrating NK subset which was also associated with improved patient prognosis. A similar favorable survival trend was projected using gene signatures for mature myeloid dendritic cells (mDC) a

SUBMITTER: Khan MAAK 

PROVIDER: S-EPMC11772185 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature