Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease.

ABSTRACT:

Objective

Chronic kidney disease (CKD) is a major global health problem. In clinical practice, the Chinese patent herbal medicine Jianpi-Yishen (JPYS) formula is commonly used to treat CKD. However, the molecular mechanisms by which JPYS targets and modulates the host immune response remain unclear.

Methods

This study utilized network pharmacology, RNA sequencing (RNA-seq), and metabolic analyses using in vivo and in vitro models to investigate the impact of the JPYS formula on inflammation and the immune system. Specifically, the study focused on macrophage polarization and metabolic changes that may slow down the progression of CKD.

Results

A total of 14,946 CKD-related targets were identified from the GeneCards and Online Mendelian Inheritance in Man

SUBMITTER: Li Y 

PROVIDER: S-EPMC11772200 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature