Brain gray matter changes in children at risk for sudden unexpected death in epilepsy.

ABSTRACT:

Background

Potential failing adult brain sites, stratified by risk, mediating Sudden Unexpected Death in Epilepsy (SUDEP) have been described, but are unknown in children.

Methods

We examined regional brain volumes using T1-weighted MRI images in 21 children with epilepsy at high SUDEP risk and 62 healthy children, together with SUDEP risk scores, calculated from focal seizure frequency. Gray matter tissue type was partitioned, maps normalized, smoothed, and compared between groups (SPM12; ANCOVA; covariates, age, sex, and BMI). Partial correlations between regional volumes and seizure frequency were examined (SPM12, covariates, age, sex, and BMI); 67% were at high risk for SUDEP.

Results

The cerebellar cortex, hippocampus, amygdala, putamen, cingulate, thalamus, and

SUBMITTER: Roy B 

PROVIDER: S-EPMC11772226 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature