Assessment of extremely premature lambs supported by the Extrauterine Environment for Neonatal Development (EXTEND).

ABSTRACT:

Background

Our team has previously reported physiologic support by the EXTra-uterine Environment for Neonatal Development (EXTEND) of 105 to 117 days gestational age (GA) lambs for up to 28 days with normal organ maturation. However, the fetal lamb brain matures more rapidly, requiring the study of 90-105 day GA fetal lambs to assess more neurodevelopmentally equivalent lambs to the 23-25 week GA extreme premature infant.

Methods

Extremely preterm lambs (90-95 days of GA) were delivered by C-section and supported by EXTEND. Estimated circuit flows were maintained at around 325 ml/kg/min. After support on EXTEND, MRI and histopathologic analysis were performed and compared to 105-112 days GA control lambs.

Results

The extremely preterm group includes 10 animals with a

SUBMITTER: Peers de Nieuwburgh M 

PROVIDER: S-EPMC11772227 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature