Innovative epitopes in <i>Staphylococcal</i> Protein-A an immuno-informatics approach to combat MDR-MRSA infections.

ABSTRACT:

Background

Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant challenge in clinical environments due to its resistance to standard antibiotics. Staphylococcal Protein A (SpA), a crucial virulence factor of MRSA, undermines host immune responses, making it an attractive target for vaccine development. This study aimed to identify potential epitopes within SpA that could elicit robust immune responses, ultimately contributing to the combat against multidrug-resistant (MDR) MRSA.

Methods

The SpA protein sequence was retrieved from the UniProt database, with various bioinformatics tools employed for epitope prediction. T-cell epitopes were identified using the Tepitool server, focusing on high-affinity interactions with prevalent human leukocyte

SUBMITTER: Zhou P 

PROVIDER: S-EPMC11772303 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature