Transcutaneous vagus nerve stimulation for Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Transcutaneous vagus nerve stimulation (tVNS) has emerged as a novel noninvasive adjunct therapy for advanced Parkinson's disease (PD), yet no quantitative analysis had been conducted to assess its therapeutic effect.

Objectives

This review aimed to investigate the efficacy of tVNS on motor function, other potential clinical targets and its safety in various treatment conditions.

Methods

We searched six databases for randomized controlled trials (RCTs) that involved treating PD patients with tVNS. Primary outcome was motor functions, including severity of motor signs, functional mobility and balance, and gait parameters. Secondary outcomes were cognition, emotion, sleep related impairments, patient reported non-motor outcomes, and any adverse events. All ou

SUBMITTER: Shan J 

PROVIDER: S-EPMC11772336 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature