Plasma Proteomes and Genome-Wide Association Data for Causal Protein Identification in Stroke.

ABSTRACT: Plasma proteins are promising biomarkers and potential drug targets for stroke. This study aimed to explore whether there is a causal relationship between plasma proteins and subtypes of stroke using a Mendelian randomization (MR) approach. A two-sample bidirectional Mendelian randomization approach was employed to investigate the causal link between plasma proteins and stroke. Data on plasma proteins were obtained from three studies, including INTERVAL, and pooled stroke information was sourced from the MEGASTROKE consortium and the UK Biobank dataset, covering four subtypes of stroke. MR analyses were primarily conducted using inverse variance weighting, and sensitivity analyses were also performed. Finally, potential reverse causality was assessed using bidirectional MR. We identified t

SUBMITTER: Xu L 

PROVIDER: S-EPMC11772457 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature