Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases.

ABSTRACT: The brain-gut axis constitutes the basis for the bidirectional communication between the central nervous system and the gastrointestinal tract driven by neural, hormonal, metabolic, immunological, and microbial signals. Alterations in the gut microbiome composition as observed in inflammatory bowel diseases can modulate brain function and emerging empirical evidence has indicated that interactions among the brain-gut microbiome-axis seem to play a significant role in the pathogenesis of both inflammatory bowel diseases and psychiatric disorders and their comorbidity. Yet, the immunological and molecular mechanisms underlying the co-occurrence of inflammatory bowel diseases and psychological symptoms are still poorly understood. The aim of this narrative review is to highlight contemporary

SUBMITTER: Atanasova K 

PROVIDER: S-EPMC11772462 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature