Meta-analysis of retinal transcriptome profiling studies in animal models of myopia.

ABSTRACT:

Objective

Myopia prevalence is increasing at alarming rates, yet the underlying mechanistic causes are not understood. Several studies have employed experimental animal models of myopia and transcriptome profiling to identify genes and pathways contributing to myopia. In this study, we determined the retinal transcriptome changes in response to form deprivation in mouse retinas. We then conducted a transcriptome meta-analysis incorporating all publicly available datasets and analyzed how the results related to the genes associated with refractive errors in human genome-wide association studies (GWAS).

Methods

Form deprivation was induced in three male C57BL6/J mice from postnatal day 28 (P28) to P42. Retinal gene expression was analyzed with RNA sequencing, followed by diffe

SUBMITTER: Palumaa T 

PROVIDER: S-EPMC11772478 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature